MOLECULAR PATHOLOGY OF LUNG ADENOCARCINOMA

POPESCU IULIAN PhD, MD, Clinical Department of Radio-Biology at the Fundeni Clinical Institute in Bucharest

e-mail: popdociul@yahoo.com

              ALINA HALPERN PhD, SF.ŞTEFAN Hospital  Bucharest

INTRODUCTION.

Lung Cancer (C:P.) develops through the accumulation of multiple alterations molecular, genetic and epigenetic causing the aberrant gene functioning. Aneusomya (the presence of an abnormal number of chromosomes) is associated with lung cancer. It has not been defined yet whether aneumosomya also exists in pre-neoplastic lesions (3)). Smoking is an important etiologic factor. The tobacco components facilitates tumorigenesis through genotoxic efects and by modeling the signaling pathways.
            Lung cancer still remains a serious illness, the number of deaths exceeding deaths following the cancer of prostate, breast and colon taken together. The five-year survival remained 15 %, instead in the other locations increased up to 64 % of colon cancer , 88 % breast cancer and 99 % prostate cancer  (4.1)

MOLECULAR PATHOLOGY OF THE SQUAMOUS FORM OF NON-SMALL CELL LUNG CANCER

 POPESCU IULIAN PhD, MD, Clinical Department of Radio-Biology at the Fundeni Clinical Institute in Bucharest

e-mail: popdociul@yahoo.com

              ALINA HALPERN PhD, SF.ŞTEFAN Hospital  Bucharest

INTRODUCTION

Study of the molecular pathology of lung cancer (LC) has contributed and is further contributing to a more deepened knowledge of pre-neoplastic lesions, of carcinogenesis process, of metastatic invasion and disseminations. By simultaneously highlighting multiple markers the early diagnosis becomes possible in the targeted treatment of LC. So far the LC treatment was a uniform treatment for a heterogeneous disease. These cumulated data give hope for the increase of survival rate, which currently is one of the lowest

LARGE CELL LUNG CANCER. ISSUES OF MOLECULAR PATHOLOGY

POPESCU IULIAN PhD, MD, Clinical Department of Radio-Biology at the Fundeni Clinical Institute in Bucharest

e-mail: popdociul@yahoo.com

             ALINA HALPERN PhD, SF.ŞTEFAN Hospital  Bucharest

Classification of Lung Cancer (LC) is primarily performed in morphological terms and in particular through immunohistochemical methods.

Large cell carcinomas are a distinct group of tumors within the non-small cell lung cancer.

The diagnosis of large cell lung cancer - until now - is made by the exclusion of other forms of lung cancer (LC)

Wtihin large cell lung cancer it is observed - at ultrastructural level - conformations of squamous or glandular differentiation (1,2,3)

Large cell lung cancer has a number of sub-categories: