THE CANCER STEM CELLS AND LUNG CANCER

POPESCU IULIAN PhD,MD, Clinical Department of Radio-Biology at the Fundeni Clinical Institute in Bucharest

e-mail popdociul @yahoo.com

Dr. ALINA HALPERN PhD, SF.ŞTEFAN Hospital  Bucharest

It is well recognized that lung localization of the cancer is one with the weakest therapeutic results, with all scientific conquests as concerns the therapies obtained from 1950 until today. Surviving more than 5 years is below 15%, compared to results from other localizations (99% in prostate cancer, 86% in breast cancer, 66% for colon cancer, 30% in ENT sphere cancer). In lung cancer encouraging results have been obtained in the possibility of increasing the survival time without relapse (disease free survival), but not also concerning the overall survival. The main task in the treatment of lung cancer remains the prolongation of overall survival and

THE MOLECULAR PATHOLOGY OF THE CHRONIC OBSTRUCTIVE BRONCHOPNEUMOPATHY

POPESCU IULIAN PhD, MD, Clinical Department of Radiobiology

FUNDENI CLINICAL HOSPITAL OF BUCHAREST

e-mail: popdociul@yahoo.com

Dr.ALINA HALPERN - PhD

The Lung Disease Hospital "Sf. Stefan", Bucharest

ABSTRACT.

THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) is characterized by the progressive airways narrowing and air flow limitation and related to an abnormal inflammatory process. In the inflammatory process take part: the structural cells, cells of the inherited and adaptive immunity: neutrophils, macrophages, T lymphocytes with the predominance of the Tc1 cells. Under the action of the etiologic factors multiple inflammatory mediators are released with the help of the transcription factor NFkappaB. These play a key role in orchestrating the chronic inflammation through their chemotactic and proinflammatory action. The chronic inflammation progresses in a very complex manner through the interaction of the native and adaptive immunity cells with the inflammation cytokines and mediators. The molecular basis of inflammation enlargement of is not well known, but it is - in part - genetically determined.